Publications

Professor Bernard Yan’s 324 academic papers include 1 (as co-first author) published in Lancet, 1 (as co-corresponding) published in JAMA and 5 (as co-author) published in the New England Journal of Medicine. In particular, the Lancet paper (Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset) showed that bridging therapy was associated with better outcomes. This has effected significant change in stroke treatment guidelines worldwide. There are many clinical papers published in flagship academic journals: JAMA, JAMA Neurology, Lancet Neurology, Circulation and Stroke.

Top 5 Recent publications (* indicates first or co-first or senior corresponding author status)

h-index = 66

  1. Mitchell PJ, Yan B*, Churilov L, Dowling RJ, Bush SJ, Bivard A, Huo XC, Wang G, Zhang SY, Ton MD, Cordato DJ, Kleinig TJ, Ma H, Chandra RV, Brown H, Campbell BCV, Cheung AK, Steinfort B, Scroop R, Redmond K, Miteff F, Liu Y, Duc DP, Rice H, Parsons MW, Wu TY, Nguyen HT, Donnan GA, Miao ZR, Davis SM; DIRECT-SAFE Investigators. Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial. Lancet. 2022 Jul 9;400(10346):116-125. doi: 10.1016/S0140-6736(22)00564-5. PMID: 35810757.

  2. Miao Z, Luo G, Song L, Sun D, Chen W, Yao X, Pan Y, Liu Y, Yuan G, Wen C, Wei M, Cai X, Yang Q, Zhou Z, Chang M, Nan G, Wang J, Xiang G, Zhou L, Gao W, Zhang H, Hao J, Xu C, Sun Y, Yi T, Feng G, Han H, Gao F, Ma N, Mo D, Sun X, Deng Y, Tong X, Li X, Jia B, Wang B, He Z, Yang M, Zhao X, Zhang X, Zhang L, Li S, Tong X, Jing J, Xiong Y, Liu T, Li Z, Ren Z, Wang Y, Liebeskind DS, Jovin TG, Nguyen TN, Wang Y, Liu L, Yan B*, Huo X; ANGEL-TNK Investigators. Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy: The ANGEL-TNK Randomized Clinical Trial. JAMA. 2025 Jul 5:e2510800. doi: 10.1001/jama.2025.10800. Epub ahead of print. PMID: 40616323; PMCID: PMC12228980.

  3. Tan Z, Parsons M, Bivard A, Sharma G, Mitchell P, Dowling R, Bush S, Churilov L, Xu A, Yan B*. Comparison of Computed Tomography Perfusion and Multiphase Computed Tomography Angiogram in Predicting Clinical Outcomes in Endovascular Thrombectomy. Stroke. 2022 Jun 24:101161STROKEAHA122038576. doi: 10.1161/STROKEAHA.122.038576. Epub ahead of print. PMID: 35748291.

  4. Tan Z, Parsons M, Bivard A, Sharma G, Mitchell P, Dowling R, Bush S, Xu A, Yan B*. Optimal Tissue Reperfusion Estimation by Computed Tomography Perfusion Post-Thrombectomy in Acute Ischemic Stroke. Stroke. 2021 Dec;52(12):e760-e763. doi: 10.1161/STROKEAHA.121.034581. Epub 2021 Oct 21. PMID: 34670411.

  5. Lim JC, Churilov L, Bivard A, Ma H, Dowling RJ, Campbell BCV, Parsons MW, Davis SM, Donnan GA, Mitchell PJ, Yan B*. Does Intravenous Thrombolysis Within 4.5 to 9 Hours Increase Clot Migration Leading to Endovascular Inaccessibility? Stroke. 2021 Mar;52(3):1083-1086. doi: 10.1161/STROKEAHA.120.030661. Epub 2021 Feb 16. PMID: 33588590.

Professor Bernard Yan

Neurointervetion Expertise

  1. Shokri MJ, Desai N, Rao AS, Kusuma Y*, Yan B, Palaniswami M. Entropy-Guided Slice Selection for Weakly Supervised Binary ASPECTS Classification from Non-Contrast CT. 2025 International Conference on Digital Image Computing: Techniques and Applications (DICTA). 2025 Dec 3–5. Electronic ISBN: 979-8-3315-7145-0.

  2. Lee TH, Uchiyama S, Kusuma Y, Chiu HC, Navarro JC, Tan KS, Pandian JD, Guo L, Wong Y, Venketasubramanian N; for the Asian Stroke Advisory Panel. A Systematic Search and Review of Registered Pharmacological Therapies Investigated to Improve Outcomes after a Stroke. Cerebrovasc Dis Extra. 2024;14(1):158–164. doi:10.1159/000541703. PMID: 39397604.

  3. Kusuma Y*, Che B, Pillai P, et al. CT perfusion identified potential treatment opportunities in one in five mild strokes. Neurological Research and Practice. 2025;7:85. doi:10.1186/s42466-025-00442-8.

  4. Kusuma Y*, Clissold B, Riley P, Talman P, Wong A, Yeo LLL, Bustami M, Kiemas LS, Putri IA, Kemal MAR, Arpandy RA, Melita M, Yan B, Yielder P. Possible Influence of Ethnicity on Computed Tomography Perfusion Parameter Thresholds in Acute Ischaemic Stroke. Cerebrovasc Dis. 2024;53(3):245–251. doi:10.1159/000533384. PMID: 37549646.

  5. Venketasubramanian N, Kusuma Y*, Yeo LLL, Chan B. Direct-Acting Oral Anticoagulant Dabigatran as a Bridging Therapy while Optimizing Warfarin Dosage for Cardioembolic Stroke. Cerebrovasc Dis Extra. 2025;15(1):48–55. doi:10.1159/000543301. PMID: 39709948.

  6. Beppu M, Kusuma Y*, Yoshimura S, Lee JS, Yan B. Mechanical Thrombectomy in Patients With Acute Stroke Having Concurrent Intracranial Hemorrhage: Navigating a Clinical Dilemma. J Stroke. 2026;28(1):178–180. Published online Jan 2, 2026. doi:10.5853/jos.2025.02236.

  7. Nie X, Che B, Qin X, Kusuma Y*, Houlihan C, Pan Y, Yan H, Yang J, Wei Y, Miao Z, Liu L, Mitchell P, Yan B. A Simple and Pragmatic Equation for Rapid Outcome Prediction in Endovascular Thrombectomy With Limited Information. J Am Heart Assoc. 2024;14(24). doi:10.1161/JAHA.124.04035.

Neurologist Subspecialty Stroke, Neurosonology & Movement Disorders

Dr Yohanna Kusuma